Design and formulation of optimized microemulsions for. Phase behavior, particle size, viscosity and solubilization. The preparation of microemulsion as a nanocarrier and its application for the delivery of chemical drugs has been the subject of growing studies. Microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and cosurfactant, can. Formulation and characteristics of nicotinamideloaded microemulsions. Preparation and evaluation of vancomycin microemulsion for ocular drug delivery authors. Formulation, characterization, and clinical evaluation of. Preparation and evaluation of microemulsionbased transdermal. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible.
Most remarkable finding was that the antiinflammatory activity exhibited by aceclofenac microemulsion based emulgel. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. Formulation and evaluation of microsponge gel for topical delivery of the antifungal drug. Preparation and evaluation of fexofenadine microemulsion. Moreover, the effectiveness of the formulation in delivering the drug as manifested in vitro and ex vivo studies, was transposed into significantly mitigating smulgel in animal models. Preparation, optimization and characterization of microemulsions 169 to different oils, surfactants and cosurfactants and stirred on magnetic stirrer for 24 hours. Pseudoternary phase diagrams were constructed using water titration method at 252c to obtain the appropriate components, and their concentration ranges that resulted in a large existence area of microemulsion were chosen. Among three types of microemulsion, namely oilinwater, waterinoil and bicontinuous, the first type is more useful in delivering oilsoluble drug molecules atashafrooz et al. The method is significantly more straightforward than other extant methods. In order to develop an alternative formulation for the topical administration of np, microemulsions were evaluated as delivery vehicles. Pharmacodynamic evaluation also indicated lesser intensity of seizures in rats treated with optimized formulation in comparison to rats treated with oral carbamazepine microemulsion and nasal carbamazepine solution which suggested carbamazepine transnasal. The objective of this work was to prepare and evaluate sa me systems. Preparation and evaluation of microemulsion containing antihypertensive drug article pdf available in international journal of applied pharmaceutics 105. Characterization of microemulsion the formulated microemulsion exhibited mean droplet size of 35.
Formulation and characterization of microemulsion based gel. Preparation and evaluation of microemulsion systems containing. Particle size and zeta potential measurements ispersity index pdi of me. To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and cosurfactant was developed for intranasal delivery. The optimized microemulsion formulation b9 was subjected for various evaluation parameters such as, visual inspection, stability studies, ph, viscosity. Evaluation of microemulsion based hydrogel globule size determination the average droplet size of samples was measured at 25c by malvern zeta sizer. Pseudoternary phase diagrams were constructed to identify the area of microemulsion existence. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i.
Together with classical applications in detergency and lubrication, the field remains sufficiently important to continue to attract a number of scientists. The samples were also analysed for their particle size and size distribution, viscosity, conductivity and birefringence. A topical preparation containing aceclofenac was developed using an ow microemulsion system. Preparation of microemulsion microemulsion was prepared by dissolving acyclovir in ipm and tween 80. One of the modern drug carriers which are widely researched are microemulsions. Formulation, optimization and evaluation of atorvastatin. For topical delivery semisolid preparation are widely accepted over solid and liquid dosage forms. Preparation and evaluation of microemulsion systems. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Accelerated stability study of the developed microemulsion was carried out for 6 months. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant.
Fixed quantity of smedds is added to fixed quantity of suitable medium under continuous stirring 50 rpm on. The amount of surfactant and cosurfactant to be added and the percent of oil. The increased incidence of inflammatory diseases has. The microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. Development and evaluation of microemulsion based gel mbgs. Glimepiride loaded microemulsion using labrafil m 1944 cs, cremophor rh 40, transcutol p as oil, surfactant and cosurfactant respectively, was prepared and characterized. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid an me gel base composed of 35% ipm, 20% water, and 45% tween 80. Physicochemical, in vitro and in vivo evaluation of flurbiprofen. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of.
Drug solubilization capacity of the microemulsion system was determined. A reverse microemulsion differs from an emulsion in that the tail groups of the surfactants orientate outwards microemulsions. For other materials, the microemulsion contains all above plus one. Guidance document for the conduct of skin absorption studies. Formulation, optimization and evaluation of atorvastatin calcium loaded microemulsion. Preparation and evaluation of microemulsion mafiadoc. Formulation and characterization of microemulsion system.
Isopropyl myristate was chosen as the oil phase as it showed a good solubilising capacity. Microemulsions for oral administration and their therapeutic. Preparation and evaluation of flurbiprofenloaded microemulsion for parenteral delivery preparation and evaluation of flurbiprofenloaded microemulsion for parenteral delivery park, kyungmi. The use of microemulsion as delivery systems can improve the efficacy of a drug, allowing the total dose to be reduced and thus minimizing side effects. In order to prepare the drug loaded microemulsions, a stock solution containing econazole nitrate was prepared with the mixture of. Preparation and evaluation of microemulsionbased transdermal delivery of total flavone of rhizoma arisaematis lina shen,1 yongtai zhang,1 qin wang,2 ling xu,2 nianping feng11department of pharmaceutical sciences, 2department of oncology, longhua hospital, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. Characterization of microemulsions prepared using isopropyl. The monophasic microemulsion was formed spontaneously at.
Microemulsion region from pseudoternary phase diagram was selected for miglyol 810. The samples were centrifuged at 8000 rpm for 10 minutes and the drug content in the supernatant was analysed after proper dilution with methanol as described in. Preparation and evaluation of microemulsion formulations of. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials. Preparation and evaluation of vancomycin microemulsion for ocular drug delivery volume. Preparation and evaluation of aceclofenac topical microemulsion. Preparation and evaluation of selfmicroemulsifying drug delivery system of oridonin ping zhang. Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam. Wo nanoemulsions can also be prepared in a similar fashion by reversing the dispersed and continuous phases. Preparation of drug solution the olz solution os meant for comparative evaluation of mmebased systems was prepared by dissolving olz 80 mg in 10 ml of propylene glycol resulting in a solution of 8 mgml kumar et al. The solubility of aceclofenac in different oils, surfactants and cosurfactants was determined since formulaton is the most important criteria for microemulsion preparation table 2. Jul 09, 2019 evaluation of microemulsion 4 7 appearance and ph.
Use of a large concentration of surfactant and cosurfactant necessary for stabilizing the nanodroplets. Enhanced systemic exposure and efficacy of diltiazem from novel. Therefore, one should characterize microemulsion structures in detail for improving novel and effective techniques and applications. Preparation and evaluation of selfmicroemulsifying drug. It belongs to the ii class of bcs classification hence formulating a microemulsion will increase its solubility dissolution and thus improves the oral bioavailability.
The traditional way of preparation of microemulsion. Microemulsions mes are clear, thermodynamically stable systems. Design and evaluation of microemulsion gel system of. However, further emulyel is warranted focusing on formulation stability and more in vivo studies to substantiate the potential of the emulgel formulation as robust and efficacious.
Preparation, optimization and characterization of microemulsions 167 5. Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. The phase behaviour and nano and microemulsion formation of the ternary mixtures prepared were characterised by visual observation for their phase separation and optical clarity e. Electrical conductivity measurement is a tool for the evaluation stability shortly after preparation. Microemulsion are having unique properties, namely, ultralow interfacial tension, large interfacial area, thermodynamic stability and the ability.
For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol. Preparation of nicotinamide microemulsions and formulation. Different concentrations of sa were incorporated in an me base composed of isopropyl. Formulation and evaluation of microemulsionsbased drug. Microemulsions are prepared by the spontaneous emulsification method phase. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Five ctm microemulsion formulations m1m5 were prepared. An assessment of transparency is commonly used to define the microemulsion zone in pseudoternary diagrams. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. A mixture experimental design with five independent variables x 1. Nepheloturbidimetric evaluation can be performed to monitor the growth of droplets in microemulsions. The drug is be dissolved in the lipophilic part of the microemulsion i.
Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. This article is from jundishapur journal of natural pharmaceutical products, volume 8. A microemulsion forming systems is shown in figure 1. Full text preparation and evaluation of microemulsion. Apr 06, 2020 formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam. Preparation, characterization and invivo evaluation of. Formulation and evaluation of microemulsion based topical. Preparation of microemulsions based gels after the microemulsion regions in the phase diagrams were identified, the microemulsion formulations were selected at different component ratios as described in table1. Formulation and evaluation of microemulsionbased hydrogel for. Microemulsion can be generated rapidly upon gentle mixing with water or aqueous media. Pdf preparation and evaluation of novel microemulsion. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34.
Microemulsion, vancomycin, drug delivery, ternary phase diagrams, ocular irritation, in. The objective of the present study was to formulate and evaluate microemulsion systems for topical delivery of clotrimazole ctm. Solutol hs 15 system highest region was found in 1. Pdf formulation and evaluation of microemulsionbased. Preparation and evaluation of transnasal microemulsion of. Preparation and evaluation of microemulsion formulations. Microemulsion as a carrier for nose to brain targeting. Pseudoternary phase diagrams were used to obtain the concentration ranges of the oil, surfactant labrasol and cosurfactant plurol oleique for microemulsion. A large number of oils and surfactants can be used for microemulsion.
Formulation and evaluation of microemulsionbased hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Formulation and characterization of microemulsion based. Preparation and evaluation of novel microemulsion based hydrogels for dermal delivery of benzocaine. Aug 08, 2019 the solubility of aceclofenac in different oils, surfactants and cosurfactants was determined since formulaton is the most important criteria for microemulsion preparation table 2. Salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. Pdf preparation and evaluation of microemulsion formulations of. Finally, fixed amount of triethanolamine was added to get different hydrogel thickened microemulsions batches f1f9, table 2. Development and evaluation of microemulsion based gel. Following are the different methods used for the preparation of the microemulsions. This may be considered as an extension of w insors classification form ing the fifth category. Five ctm microemulsion formulations m1m5 were prepared and. Preparation of nano and microemulsions using phase. An external file that holds a picture, illustration, etc. Formulation development and characterization of microemulsion drug delivery systems containing antiulcer drug.
The aim of the present study was to design a microemulsion for catechin topical application. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Additionally, formulation of carbopoli microemulsion showed higher. Dhakar r, maurya1 s, gupta a, jain a, kiroriwal s, gupta m. Department of pharmaceutics, sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, andhra pradesh, india517102. The solubility of ctm in various oils was determined to select the oil phase of the microemulsion systems.
Microemulsion formulation design and evaluation for. Most remarkable finding was that the antiinflammatory activity exhibited by. It is thought that the microemulsion is spontaneously formed by the combined action. They were used to solubilize drugs and to improve topical drug availability. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. It was found that optimized microemulsion was stable and transparent with average globule size of 190 nm and diffusion flux of 75. Atorvastatin calcium is a hmgcoa inhibitor having an antihyperlipidemic effect. Rahul nair, department of pharmaceutics, sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, andhra pradesh, india517102. Preparation and characterization of nicotinamideloaded microemulsions 35 3. A microemulsion preparation of nanoparticles of europium. Pg as surfactantcosurfactant mixture scos in ratio of 15.
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